PDE9A ELISA Kit for Human(Homo sapiens) | EIAab.comPDE9A ELISA Kit for Human(Homo sapiens)

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PDE9A (Gene name),

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Protein name ), PDE9A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PDE9A;

Protein name:

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

Subcellular Location:

Isoform PDE9A17 Cytoplasm Endoplasmic reticulum

Protein Attributes:

Sequence length:

593

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

593:

EELKRIDDAM | KELQKKTDSL | TSGATEKSRE | RSRDVKNSEG | DCA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:5152

String:

O76083

UniGene:

Hs.473927

SMR:

O76083

MIM:

602973

Pfam:

PF00233

Uniprot:

O76083

FOR

ELISA Kit for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

E12007h

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Packing:

96T

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ELISA Kit for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

E12007m

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MSDS:

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Packing:

96T

CLIA Kit for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

U12007m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

U12007h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

P12007Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Cat.:

P12007Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Protein for Human High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase."
Fisher D.A. , Smith J.F. , Pillar J.S. , St Denis S.H. , Cheng J.B.
J. Biol. Chem.273:15559-15564(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE9A1)
tissue: Brain.
tissue: Prostate.
tissue: Testis.
2.

"Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence."
Guipponi M. , Scott H.S. , Kudoh J. , Kawasaki K. , Shibuya K. , Shintani A. , Asakawa S. , Chen H. , Lalioti M.D. , Rossier C. , Minoshima S. , Shimizu N. , Antonarakis S.E.
Hum. Genet.103:386-392(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS PDE9A1; PDE9A2; PDE9A3 AND PDE9A4)
tissue: Fetal brain.
3.

"Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene."
Rentero C. , Monfort A. , Puigdomenech P.
Biochem. Biophys. Res. Commun.301:686-692(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE9A5; PDE9A6; PDE9A7; PDE9A9; PDE9A10; PDE9A11; PDE9A12; PDE9A13; PDE9A16; PDE9A17 AND PDE9A18);TISSUE SPECIFICITY
4.

"Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants."
Wang P. , Wu P. , Egan R.W. , Billah M.M.
Gene314:15-27(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE9A6)
tissue: Brain.
tissue: Small intestine.
tissue: Spleen.
5.

"Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene."
Rentero C. , Puigdomenech P.
BMC Mol. Biol.7:39-39(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE9A21);SUBCELLULAR LOCATION
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PDE9A1 AND PDE9A3)
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE9A2)
8.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE9A2)
tissue: Eye.
11.

"Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding."
Huai Q. , Wang H. , Zhang W. , Colman R.W. , Robinson H. , Ke H.
Proc. Natl. Acad. Sci. U.S.A.101:9624-9629(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 241-566 IN COMPLEX WITH THE INHIBITOR IBMX
12.

"Structural basis for the catalytic mechanism of human phosphodiesterase 9."
Liu S. , Mansour M.N. , Dillman K.S. , Perez J.R. , Danley D.E. , Aeed P.A. , Simons S.P. , Lemotte P.K. , Menniti F.S.
Proc. Natl. Acad. Sci. U.S.A.105:13309-13314(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 242-566 IN COMPLEX WITH MAGNESIUM; MANGANESE; ZINC; GMP AND CGMP;FUNCTION;COFACTOR;MUTAGENESIS OF HIS-312 AND HIS-356
13.

"Crystal structure of the human phosphodiesterase 9a catalytic domain."
RIKEN structural genomics initiative (RSGI)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 241-566

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